Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate. It begins with a reversible state called acinar-to-ductal metaplasia, where cells ...

Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

Modeling the economic impact of a CIZ1B biomarker blood test for lung cancer screening in high-risk populations. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract ...

Deep in our cells, a wide range of processes are occurring constantly. These cellular processes rely on enzymes to act as catalysts and set off a series of molecular interactions. There are still many ...

The mutational spectrum of fibroblast growth factor receptor 3 (FGFR3) in individuals with achondroplasia. In humans, the mutations associated with achondroplasia patients are mainly located in ...

Precision medicine company CareDx and 10x Genomics have partnered to launch ImmuneScape, a multiomics program to improve the understanding of transplant organ rejection and variability in patient ...

Emerging research suggests that lifestyle factors including exercise, nutrition and heat exposure may influence the cellular pathways that drive aging. Most of us learned that aging results from the ...

Scientists have uncovered a startling metabolic twist: mice engineered to lack the amino acid cysteine, and fed a cysteine-free diet, shed nearly a third of their body weight in just a week. The ...

Throughout evolutionary history, there have been genetic elements that have duplicated - giving rise to genes with different functions. These are called 'paralogs'. They are able to form and evolve ...

Early mammalian ancestors were nocturnal, sleeping during the day while the dinosaurs dominated the land. However, some mammalian lineages, including human ancestors, independently transitioned to ...