When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

Summary image of the article. The upper part highlights neuronal cell cycle re-engagement is a stage proceeding neuronal senescence and that their full molecular profiles can now be identified by the ...

Using drugs that inhibit enzymes called CDK4/6 and CDK2 extends the G1 phase of the cell cycle and helps to slow the growth of drug-resistant breast cancer.

Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this re-entry is more common in Alzheimer's disease, according to a new study. The phenomenon may ...