Pasca Lab specializes in growing three-dimensional organoid models from reprogrammed stem cells, which capture molecular changes during fetal brain-like development. Because the human brain cannot be ...

Some single-celled organisms are known to transition to multicellularity during their lifetimes, usually either by cloning themselves or when many similar cells come together to form a larger ...

Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

A wave of recent neuroscience research has identified specific molecular and cellular mechanisms through which alcohol disrupts signaling between brain cells, offering a sharper picture of how ...

Researchers in Japan have identified a striking new way immune cells strip DNA out of dying neighbors, a process they call ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

The integration of single-cell and spatial transcriptomics with advanced metabolic profiling tools has revolutionized the ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

A new review was published as the cover paper of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15, entitled, "Types of cell death and their ...

Researchers have for the first time identified degeneration-associated “molecular markers” —observable changes in cells and their gene-regulating networks—that are shared by several forms of dementia ...

New research shows that physical pressure from brain tumors or injuries triggers a "self-destruction" program in neurons, leading to irreversible brain damage.