Many cancer-driving mutations disable a key checkpoint in the cell’s cycle between growth and division, resulting in unchecked activity of the E2F family of transcription factor proteins. A set of ...

New research from Dana-Farber Cancer Institute shows that a new class of drug results in cell death in cancers, such as small cell lung cancer, with a disabled quality control cell cycle checkpoint ...

The awe-inspiring process of cell division can turn a fertilized egg into a baby—or a cancerous cell into a malignant tumor. With so much at stake, nature keeps it tightly controlled in a process ...