A new comprehensive review reveals that harnessing natural killer (NK) cells by blocking their “off-switches” could significantly enhance cancer immunotherapy, providing new avenues for treating solid ...

The interplay between immune responses and cell death pathways is a central theme in immunology and pathology. Recent developments emphasize that these ...

T cell checkpoint modulation harnesses or inhibits natural regulatory pathways that control T cell activation, proliferation and survival. Central to this approach are inhibitory receptors such as ...

Immune checkpoint inhibitors are cancer therapeutics that have shown remarkable success in extending lives in many cancers, including melanoma, MSI-high cancers, and other cancers. However, these ...

Researchers in the lab of Jean Cook, Ph.D., chair and professor in the Department of Biochemistry and Biophysics, have identified the cellular processes that occur when you take a cancer drug meant to ...