It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment. Researchers show that expansion of bone marrow fat promotes immunosuppressive PD-L1 ...

Alternative Methods for Evaluating Bone Health While DEXA is the standard for a bone health evaluation, alternative methods, including quantitative ultrasound (QUS) and peripheral dual-energy X-ray ...

As we age, the health of our bones becomes increasingly important. Osteoporosis, a condition characterized by weakened bones, affects millions, leading to fractures and reduced quality of life. Among ...