Researchers from TMDU find that CD22 restores B cell function in B cell receptor (BCR) signaling deficiencies by interacting with cis-ligands and upregulating BCR expression, thereby paradoxically ...

This article was supported by Regione Veneto, Ricerca Sanitaria Finalizzata; Fondazione G Berlucchi per la Ricerca sul Cancro; Fondazione Cassa di Risparmio di Verona, Vicenza, Belluno e Ancona and ...

The KLHL14 gene acquires frequent inactivating mutations in mature B cell malignancies, especially in the MYD88L265P, CD79B mutant (MCD) genetic subtype of diffuse large B cell lymphoma (DLBCL), which ...

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B ...

Researchers from Osaka University find that the tyrosine kinase Csk inhibits germinal center B cell signaling, thereby decreasing the production of reactive oxygen species and apoptosis, and promoting ...

The prominent role of the BCR signaling in promoting B-CLL cell survival has prompted new therapeutic strategies targeted to signalosome elements. In particular, the most advanced BCR-signaling ...